Regulated nucleocytoplasmic transport in spermatogenesis: a driver of cellular differentiation?

@article{Hogarth2005RegulatedNT,
  title={Regulated nucleocytoplasmic transport in spermatogenesis: a driver of cellular differentiation?},
  author={Cathryn A. Hogarth and Catherine M Itman and David Andrew Jans and Kate L Loveland},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2005},
  volume={27 10},
  pages={1011-25}
}
This review explores the hypothesis that regulation of nucleocytoplasmic shuttling is a means of driving differentiation, using spermatogenesis as a model. The transition from undifferentiated spermatogonial stem cell to terminally differentiated spermatozoon is, at its most basic, a change in the repertoire of expressed genes. To effect this, the complement of nuclear proteins, such as transcription factors and chromatin remodelling components must change. Current knowledge of the nuclear… CONTINUE READING

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