Regulated necrosis: the expanding network of non-apoptotic cell death pathways

  title={Regulated necrosis: the expanding network of non-apoptotic cell death pathways},
  author={T. Berghe and A. Linkermann and S. Jouan-Lanhouet and H. Walczak and P. Vandenabeele},
  journal={Nature Reviews Molecular Cell Biology},
  • T. Berghe, A. Linkermann, +2 authors P. Vandenabeele
  • Published 2014
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • Cell death research was revitalized by the understanding that necrosis can occur in a highly regulated and genetically controlled manner. Although RIPK1 (receptor-interacting protein kinase 1)- and RIPK3–MLKL (mixed lineage kinase domain-like)-mediated necroptosis is the most understood form of regulated necrosis, other examples of this process are emerging, including cell death mechanisms known as parthanatos, oxytosis, ferroptosis, NETosis, pyronecrosis and pyroptosis. Elucidating how these… CONTINUE READING
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