Regulated necrosis: the expanding network of non-apoptotic cell death pathways

@article{Berghe2014RegulatedNT,
  title={Regulated necrosis: the expanding network of non-apoptotic cell death pathways},
  author={T. Berghe and A. Linkermann and S. Jouan-Lanhouet and H. Walczak and P. Vandenabeele},
  journal={Nature Reviews Molecular Cell Biology},
  year={2014},
  volume={15},
  pages={135-147}
}
  • T. Berghe, A. Linkermann, +2 authors P. Vandenabeele
  • Published 2014
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • Cell death research was revitalized by the understanding that necrosis can occur in a highly regulated and genetically controlled manner. Although RIPK1 (receptor-interacting protein kinase 1)- and RIPK3–MLKL (mixed lineage kinase domain-like)-mediated necroptosis is the most understood form of regulated necrosis, other examples of this process are emerging, including cell death mechanisms known as parthanatos, oxytosis, ferroptosis, NETosis, pyronecrosis and pyroptosis. Elucidating how these… CONTINUE READING
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    References

    SHOWING 1-10 OF 192 REFERENCES
    RIP3: a molecular switch for necrosis and inflammation.
    • 247
    • PDF
    Molecular mechanisms of necroptosis: an ordered cellular explosion
    • 1,686
    • PDF
    New components of the necroptotic pathway
    • 53
    • PDF
    Apoptosis: controlled demolition at the cellular level
    • 2,075
    • PDF
    Programmed necrosis from molecules to health and disease.
    • 139
    Antigen-mediated T cell expansion regulated by parallel pathways of death
    • 128
    • PDF
    Identification of RIP1 kinase as a specific cellular target of necrostatins.
    • 1,380
    • PDF
    Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
    • 1,840
    • PDF