Regulated interactions between partner and non-partner sensors and response regulators that control glycopeptide resistance gene expression in enterococci.

@article{Arthur1999RegulatedIB,
  title={Regulated interactions between partner and non-partner sensors and response regulators that control glycopeptide resistance gene expression in enterococci.},
  author={M Arthur and Florence Depardieu and Patrice Courvalin},
  journal={Microbiology},
  year={1999},
  volume={145 ( Pt 8)},
  pages={1849-58}
}
Transcription of the vanA and vanB glycopeptide resistance gene clusters is regulated by the VanRS and VanRBSB two-component regulatory systems, respectively. Histidine to glutamine substitutions were introduced at positions 164 of VanS and 233 of VanSB to prevent autophosphorylation of the sensor kinases and transfer of the phosphate groups to the VanR and VanRB response regulators. VanSH164Q and VanSBH233Q abolished activation of VanR and VanRB by host kinases. The phosphatase activity of… CONTINUE READING

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