Regulated externalization of phosphatidylserine at the cell surface: implications for apoptosis.

@article{Balasubramanian2007RegulatedEO,
  title={Regulated externalization of phosphatidylserine at the cell surface: implications for apoptosis.},
  author={Krishnakumar Balasubramanian and Banafsheh Mirnikjoo and Alan Jay Schroit},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 25},
  pages={18357-64}
}
The regulated loss of plasma membrane phosphatidylserine (PS) asymmetry is critical to many biological processes. In particular, the appearance of PS at the cell surface, a hallmark of apoptosis, prepares the dying cell for engulfment and elimination by phagocytes. While it is well established that PS externalization is regulated by activation of a calcium-dependent phospholipid scramblase activity in concert with inactivation of the aminophospholipid translocase, there is no evidence… CONTINUE READING

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