Regulated expression of two sets of paternally imprinted genes is necessary for mouse parthenogenetic development to term.

@article{Wu2006RegulatedEO,
  title={Regulated expression of two sets of paternally imprinted genes is necessary for mouse parthenogenetic development to term.},
  author={Qiong Wu and Takuya Kumagai and Manabu Kawahara and Hidehiko Ogawa and Hitoshi Hiura and Yayoi Obata and Riya Takano and Tomohiro Kono},
  journal={Reproduction},
  year={2006},
  volume={131 3},
  pages={481-8}
}
Mouse parthenogenetic embryos (PEs) are developmentally arrested until embryo day (E) 9.5 because of genomic imprinting. However, we have shown that embryos containing genomes from non-growing (ng) and fully grown (fg) oocytes, i.e. ng(wt)/fg(wt) PE (wt, wild type), developed to E13.5. Moreover, parthenogenetic development could be extended to term by further regulation of Igf2 and H19 expression using mice with deletion of the H19 transcription unit (H19Delta13) together with its… CONTINUE READING
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