Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.

@article{Killeen1993RegulatedEO,
  title={Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.},
  author={Nigel Killeen and Seiko Sawada and Dan R. Littman},
  journal={The EMBO journal},
  year={1993},
  volume={12 4},
  pages={1547-53}
}
During T cell development, precursor thymocytes that co-express the CD4 and CD8 glycoproteins give rise to mature progeny expressing one of these molecules to the exclusion of the other. Continued expression of only CD4 is the hallmark of mature helper T cells, whereas cytotoxic T cells express CD8 and extinguish CD4. The differentiation program that generates the two T cell subsets is likely to be intimately tied to regulation of expression of these cell surface molecules. We now describe the… CONTINUE READING

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