Regulated expression of fibronectin, laminin and related integrin receptors during the early chondrocyte differentiation.

@article{Tavella1997RegulatedEO,
  title={Regulated expression of fibronectin, laminin and related integrin receptors during the early chondrocyte differentiation.},
  author={Sara Tavella and G Bellese and Patrizio Castagnola and Iain Martin and Daniele Piccini and Roberto Doliana and Alfonso Colombatti and Ranieri Cancedda and Carlo Tacchetti},
  journal={Journal of cell science},
  year={1997},
  volume={110 ( Pt 18)},
  pages={2261-70}
}
We have investigated the expression and localization of fibronectin, laminin, and their receptors, and we used an in vitro chick chondrocyte differentiation model to define a time hierarchy for their appearance in early chondro-genesis and to determine their role in the cell condensation process. By serum fibronectin depletion/reconstitution, or GRGDSP peptide competition experiments, we show that fibronectin contributes to the initial cell-cell interactions that occur during condensation. In… CONTINUE READING

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