Regulated expression of caspase-12 gene in human retinal pigment epithelial cells suggests its immunomodulating role.

@article{Bian2008RegulatedEO,
  title={Regulated expression of caspase-12 gene in human retinal pigment epithelial cells suggests its immunomodulating role.},
  author={Z M Bian and Susan G. Elner and Victor M. Elner},
  journal={Investigative ophthalmology & visual science},
  year={2008},
  volume={49 12},
  pages={5593-601}
}
PURPOSE To investigate the expression and regulation of the short form of caspase-12, caspase-12S, in human retinal pigment epithelial (hRPE) cells. METHODS hRPE cells were stimulated by the proinflammatory agents IL-1beta (2 ng/mL) and TNF-alpha (20 ng/mL); LPS (1000 ng/mL); coculture with monocytes; the immunomodulating agent cyclosporine (Cys; 30 ng/mL); the anti-inflammatory cytokine IL-10 (100 U/mL); and the endoplasmic reticulum (ER) stress inducers tunicamycin (3 or 10 muM) and… CONTINUE READING

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