Regulated expression and temporal induction of the tail-anchored sarcolemmal-membrane-associated protein is critical for myoblast fusion.

@article{Guzzo2004RegulatedEA,
  title={Regulated expression and temporal induction of the tail-anchored sarcolemmal-membrane-associated protein is critical for myoblast fusion.},
  author={Rosa M Guzzo and Jeffery Wigle and Maysoon Salih and Edwin D. W. Moore and Balwant S Tuana},
  journal={The Biochemical journal},
  year={2004},
  volume={381 Pt 3},
  pages={
          599-608
        }
}
Sarcolemmal-membrane-associated proteins (SLMAPs) define a new class of coiled-coil tail-anchored membrane proteins generated by alternative splicing mechanisms. An in vivo expression analysis indicated that SLMAPs are present in somites (11 days post-coitum) as well as in fusing myotubes and reside at the level of the sarcoplasmic reticulum and transverse tubules in adult skeletal muscles. Skeletal-muscle myoblasts were found to express a single 5.9 kb transcript, which encodes the full-length… CONTINUE READING

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