Regulated expression and RNA processing of transcripts from the Srp20 splicing factor gene during the cell cycle
@article{Jumaa1997RegulatedEA, title={Regulated expression and RNA processing of transcripts from the Srp20 splicing factor gene during the cell cycle}, author={Hassan Jumaa and Jean Louis Gu{\'e}net and Peter J. Nielsen}, journal={Molecular and Cellular Biology}, year={1997}, volume={17}, pages={3116 - 3124} }
Eukaryotic splicing factors belonging to the SR family are essential splicing factors consisting of an N-terminal RNA-binding region and a C-terminal RS domain. They are believed to be involved in alternative splicing of numerous transcripts because their expression levels can influence splice site selection. We have characterized the structure and transcriptional regulation of the gene for the smallest member of the SR family, SRp20 (previously called X16). The mouse gene encoding SRp20…
97 Citations
The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulation
- BiologyThe EMBO journal
- 1997
An auto‐regulatory activity of an SR protein which is antagonized by a second SR protein is demonstrated for the first time, and evidence is provided that SRp20 probably enhances the recognition of the otherwise unused, weak splice acceptor of exon 4.
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- BiologyMolecular and Cellular Biology
- 1998
It is demonstrated, for the first time, that an SR splicing factor, which represents a novel member of the SR family, is encoded by a functional retropseudogene.
Evolutionary conservation and regulation of particular alternative splicing events in plant SR proteins
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- 2006
It is shown that atRSp31, a member of the RS subfamily, does not autoregulate alternative splicing of its similarily positioned intron, and Interestingly, thisAlternative splicing event is regulated by atRSZ33, which is conserved from green algae to flowering plants.
Alternative splicing of pre-mRNAs of Arabidopsis serine/arginine-rich proteins: regulation by hormones and stresses.
- BiologyThe Plant journal : for cell and molecular biology
- 2007
It is shown that the pre-mRNAs of Arabidopsis genes that encode serine/arginine-rich (SR) proteins, a conserved family of splicing regulators in eukaryotes, are extensively alternatively spliced.
SR proteins and related factors in alternative splicing.
- BiologyAdvances in experimental medicine and biology
- 2007
This chapter will focus on the current mechanistic understanding of alternative splicing regulation by SR proteins and SR-related proteins and will discuss some of the questions that remain to be addressed in future research.
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- 2013
The results suggest that stress-inducible SRSF3-TR may participate in the acceleration of cell growth through facilitating c-Jun-mediated G1 progression under stressful conditions.
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The data indicate that SRSF3 affects a global change of gene expression to maintain cell homeostasis and significantly regulates the expression of at least 20 miRNAs, including a subset of oncogenic or tumor suppressive miRNAAs.
SRSF3 represses the expression of PDCD4 protein by coordinated regulation of alternative splicing, export and translation.
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Alternative Splicing of Intron 3 of the Serine/Arginine-rich Protein 9G8 Gene
- BiologyThe Journal of Biological Chemistry
- 2001
These results, and the fact that the exon 3 and 4 ESE sequences are conserved in vertebrates, strongly suggest that the alternative splicing of intron 3 represents an important step in the regulation of the expression of 9G8.
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