Regulated degradation is a mechanism for suppressing stochastic fluctuations in gene regulatory networks.

@article{ElSamad2006RegulatedDI,
  title={Regulated degradation is a mechanism for suppressing stochastic fluctuations in gene regulatory networks.},
  author={Hana El-Samad and Mustafa Khammash},
  journal={Biophysical journal},
  year={2006},
  volume={90 10},
  pages={3749-61}
}
Cellular events that execute life programs are ordered and reproducible, despite the noise and randomness underlying their biochemical reactions. The identification of the processes that ensure this robust operation is essential not only to uncover the salient design principles in organisms, but also to forward-engineer reliable genetic networks for biotechnological and therapeutic purposes. The use of feedback for noise reduction has been suggested as a recurring motif in genetic networks. In… CONTINUE READING
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