Regulated cell death in AKI.

@article{Linkermann2014RegulatedCD,
  title={Regulated cell death in AKI.},
  author={Andreas Linkermann and Guochun Chen and Guie Dong and Ulrich Kunzendorf and Stefan Krautwald and Zheng Dong},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2014},
  volume={25 12},
  pages={
          2689-701
        }
}
AKI is pathologically characterized by sublethal and lethal damage of renal tubules. Under these conditions, renal tubular cell death may occur by regulated necrosis (RN) or apoptosis. In the last two decades, tubular apoptosis has been shown in preclinical models and some clinical samples from patients with AKI. Mechanistically, apoptotic cell death in AKI may result from well described extrinsic and intrinsic pathways as well as ER stress. Central converging nodes of these pathways are… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 110 CITATIONS, ESTIMATED 66% COVERAGE

Sirt5 Attenuates Cisplatin-Induced Acute Kidney Injury through Regulation of Nrf2/HO-1 and Bcl-2

VIEW 13 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Necroptosis in acute kidney injury: a shedding light

VIEW 17 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Molecular Mechanisms of Necrotic Cell Death in Ischemic Renal Injury

VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2014
2020

CITATION STATISTICS

  • 11 Highly Influenced Citations

  • Averaged 19 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 181 REFERENCES

Canonical and non-canonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis.

Extensive podocyte loss triggers a rapid parietal epithelial cell response.

Ischemia-reperfusion induces renal tubule pyroptosis via the CHOP-caspase-11 pathway.