Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3.

  title={Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3.},
  author={Kseniya Petrova and Seiichi Oyadomari and Linda M Hendershot and David Ron},
  journal={The EMBO journal},
  volume={27 21},
P58/DNAJc3 defends cells against endoplasmic reticulum (ER) stress. Most P58 molecules are translocated into the ER lumen, and here we report selective and stable binding to misfolded proteins by P58's TPR-containing N-terminal domain. In vitro, too, P58 binds selectively to a model misfolded protein and challenge of that complex with physiological concentrations of the ER lumenal Hsp70-type chaperone BiP encourages disassembly. BiP-induced dissociation of P58 from its substrate depends on the… CONTINUE READING

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