Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3.

@article{Petrova2008RegulatedAO,
  title={Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3.},
  author={Kseniya Petrova and Seiichi Oyadomari and Linda M Hendershot and David Ron},
  journal={The EMBO journal},
  year={2008},
  volume={27 21},
  pages={2862-72}
}
P58/DNAJc3 defends cells against endoplasmic reticulum (ER) stress. Most P58 molecules are translocated into the ER lumen, and here we report selective and stable binding to misfolded proteins by P58's TPR-containing N-terminal domain. In vitro, too, P58 binds selectively to a model misfolded protein and challenge of that complex with physiological concentrations of the ER lumenal Hsp70-type chaperone BiP encourages disassembly. BiP-induced dissociation of P58 from its substrate depends on the… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

The role of the unfolded protein response in diabetes mellitus

Seminars in Immunopathology • 2013
View 10 Excerpts
Highly Influenced

Emerging features of ER resident J-proteins in plants.

Plant signaling & behavior • 2014
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 36 references

The role of p58IPK in protecting the stressed endoplasmic reticulum.

Molecular biology of the cell • 2007
View 5 Excerpts
Highly Influenced

Mammalian expression plasmid encoding pre-pro-insulinC96Y-GFP

Proc Natl Acad Sci U S A • 2007

eIF2a phosphorylation in cellular stress responses and disease

D Ron, H Harding
In Translational Control, • 2007
View 1 Excerpt

Intracellular signaling by the unfolded protein response.

Annual review of cell and developmental biology • 2006
View 1 Excerpt

The diverse roles of J-proteins, the obligate Hsp70 co-chaperone.

Reviews of physiology, biochemistry and pharmacology • 2006
View 1 Excerpt

Similar Papers

Loading similar papers…