Regulated acid–base transport in the collecting duct

@article{Wagner2009RegulatedAT,
  title={Regulated acid–base transport in the collecting duct},
  author={Carsten A Wagner and Olivier Devuyst and Soline Bourgeois and Nilufar Mohebbi},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2009},
  volume={458},
  pages={137-156}
}
The renal collecting system serves the fine-tuning of renal acid–base secretion. Acid-secretory type-A intercalated cells secrete protons via a luminally expressed V-type H+-ATPase and generate new bicarbonate released by basolateral chloride/bicarbonate exchangers including the AE1 anion exchanger. Efficient proton secretion depends both on the presence of titratable acids (mainly phosphate) and the concomitant secretion of ammonia being titrated to ammonium. Collecting duct ammonium excretion… CONTINUE READING
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