Regulated RIPK3 Necroptosis is Produced in Cardiovascular Tissues and Cells in Dietary Magnesium Deficiency: Roles of Cytokines and Their Potential Importance in Inflammation and Atherogenesis

@inproceedings{Altura2017RegulatedRN,
  title={Regulated RIPK3 Necroptosis is Produced in Cardiovascular Tissues and Cells in Dietary Magnesium Deficiency: Roles of Cytokines and Their Potential Importance in Inflammation and Atherogenesis},
  author={Burton M. Altura and Nilank C. Shah and Gatha J. Shah and Bella T. Altura},
  year={2017}
}
Burton M Altura1-6*, Nilank C Shah1,5, Gatha J Shah1,5 and Bella T Altura1,3-6 1Department of Physiology and Pharmacology, SUNY Downstate Medical Center, Brooklyn, New York, USA 2Department of Medicine, SUNY Downstate Medical Center, Brooklyn, New York, USA 3The Center for Cardiovascular and Muscle Research, SUNY Downstate Medical Center, Brooklyn, New York, USA 4The School of Graduate Studies in Molecular and Cellular Science, SUNY Downstate Medical Center, Brooklyn, New York, USA 5Bio-Defense… Expand
5 Citations
Optical Spectroscopy and Prevention of Deleterious Brain- damaging Cerebral Vascular Effects of Co- caine by Magnesium Ions: Effects on Brain Mitochondrial Oxidase, Deoxyhemoglobin, Ceramide and Sphingomyelin Levels and Their Potential Application to Human Substance Abuse
1 Department of Physiology and Pharmacology, The State University of New York Downstate Medical Center, Brooklyn, New York, USA. 2 Department of Medicine, The State University of New York DownstateExpand
Can Giant Cell Arteritis be Prevented and Ameliorated with Magnesium and a Recently-Discovered Biologic, HDFx?
TLDR
This paper presents a meta-modelling system that automates the very labor-intensive and therefore expensive and therefore time-heavy and expensive and expensive process of cell differentiation and cell reprograming that is currently performed in the clinic. Expand
Increased Risk of Stroke using Marijuana-Cannabis Products: Evidence for Dangerous Effects on Brain Circulation and the Unrecognized Roles of Magnesium
TLDR
This paper aims to demonstrate the efforts towards in-situ applicability of nanofiltration technology in the clinical practice and to demonstrate its applicability in the rapidly changing environment. Expand
Magnesium Decreases Alcohol-induced Brain Damage and PreventsExperimentally-induced Strokes: Roles of Ceramides and PlateletActivating Factor and Potential Implications for Human Subjects withAlcohol-induced Dementia
TLDR
Overall, looking at many clinical studies, there is a clear relationship between heavy alcohol ingestion, sudden –cardiac death (SCD), and dementia [16-19]. Expand

References

SHOWING 1-10 OF 95 REFERENCES
Why is there an Association between Retinal Vein Occlusion, Vision Loss, Myocardial Infarction, Stroke and Mortality: Potential Roles of Hypomagnesaemia, Release of Sphingolipids, and Platelet-Activating Factor
TLDR
This work presents a novel and scalable approach that allows for real-time, real-world evaluation of the integrity of the experimental data and its potential to improve the quality of clinical trials. Expand
Magnesium deficiency upregulates sphingomyelinases in cardiovascular tissues and cells: cross-talk among proto-oncogenes, Mg(2+), NF-κB and ceramide and their potential relationships to resistant hypertension, atherogenesis and cardiac failure.
TLDR
The data indicate that neutral-, acid-and alkaline-SMases exist in rat cardiac and VSMCs and could provide a rational basis for the treatment and prevention of drug-resistant hypertension, atherogenesis, and difficult-to-treat forms of cardiac failure. Expand
Short-term magnesium deficiency upregulates ceramide synthase in cardiovascular tissues and cells: cross-talk among cytokines, Mg2+, NF-κB, and de novo ceramide.
TLDR
The data indicated that short-term MgD (10% normal dietary intake) resulted in the upregulation of CS in ventricular, atrial, and aortic smooth muscles coupled to the synthesis/release of 12 different cytokines/chemokines, as well as activation of NF-κB in the LV and aORTic smooth muscle and sera. Expand
Short-term magnesium deficiency downregulates telomerase, upregulates neutral sphingomyelinase and induces oxidative DNA damage in cardiovascular tissues: relevance to atherogenesis, cardiovascular diseases and aging.
TLDR
The data indicated that short-term MgD resulted in down regulation of telomerase in LV, RV, atrial and aortic muscle cells; even very low levels of water-bourne Mg(2+) either prevented or ameliorated the downregulation of telomersase. Expand
Magnesium Deficiency Results in Oxidation and Fragmentation of DNA, Down Regulation of Telomerase Activity, and Ceramide Release in Cardiovascular Tissues and Cells: Potential Relationship to Atherogenesis, Cardiovascular Diseases and Aging
Recommended Citation Altura, B. M., Shah, N. C., Shah, G. J., Pérez-Albela, J. L., & Altura, B. T. (2016). Magnesium deficiency results in oxidation and fragmentation of DNA, down regulation ofExpand
Importance of Ionized Magnesium Measurements in Physiology and Medicine and the Need for Ion-selective Electrodes
1Department of Physiology and Pharmacology, State University of New York Downstate Medical Center, Brooklyn, New York, USA 2Department of Medicine, State University of New York Downstate MedicalExpand
Magnesium deficiency upregulates serine palmitoyl transferase (SPT 1 and SPT 2) in cardiovascular tissues: relationship to serum ionized Mg and cytochrome c.
TLDR
The data suggest that MgD, most likely, causes a biosynthesis of ceramides via two pathways in cardiovascular tissues, viz., via the activation of serine palmitoyl-CoA-transferase and sphingomyelinase, which lead to apoptotic events via intrinsic and extrinsic pathways. Expand
Mg deficiency results in modulation of serum lipids, glutathione, and NO synthase isozyme activation in cardiovascular tissues: relevance to de novo synthesis of ceramide, serum Mg and atherogenesis.
TLDR
The data indicate that S-T Mg deficiency resulted in reductions in s Mg(2+), SM, PC, HDL-C and the PC/chol ratio concomitant with decreases in tissue levels of glut, leakage of cardiac CK and LDH, as well as activation of e-N OS and n-NOS in all chambers of the heart and ASM. Expand
Potential Roles of Magnesium Deficiency in Inflammation and Atherogenesis: Importance and Cross-talk of Platelet-Activating Factor and Ceramide
TLDR
Results and data from the labs strongly support roles for ceramides, PAF and PAF-like lipids in low [Mg2+]0-induced IHD and SCD. Expand
Necroptosis and Inflammation.
TLDR
Either RIPK3 deficiency or RIPK1 inhibition confers resistance in various animal disease models, suggesting that inflammation caused by necroptosis contributes to tissue damage and that inhibitors of these kinases could have therapeutic potential. Expand
...
1
2
3
4
5
...