Regulated Expression of Human Histocompatibility Leukocyte Antigen (HLA)-DO During Antigen-dependent and Antigen-independent Phases of B Cell Development

@article{Chen2002RegulatedEO,
  title={Regulated Expression of Human Histocompatibility Leukocyte Antigen (HLA)-DO During Antigen-dependent and Antigen-independent Phases of B Cell Development},
  author={Xinjian Chen and Oskar Laur and Taku Kambayashi and Shiyong Li and Robert A. Bray and Dominique A. Weber and Lars Karlsson and Peter Egede Jensen},
  journal={The Journal of Experimental Medicine},
  year={2002},
  volume={195},
  pages={1053 - 1062}
}
Human histocompatibility leukocyte antigen (HLA)-DO, a lysosomal resident major histocompatibility complex class II molecule expressed in B cells, has previously been shown to be a negative regulator of HLA-DM peptide loading function. We analyze the expression of DO in human peripheral blood, lymph node, tonsil, and bone marrow to determine if DO expression is modulated in the physiological setting. B cells, but not monocytes or monocyte-derived dendritic cells, are observed to express this… CONTINUE READING

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