Regulated, side-directed secretion of proguanylin from isolated rat colonic mucosa.

@article{Martin1999RegulatedSS,
  title={Regulated, side-directed secretion of proguanylin from isolated rat colonic mucosa.},
  author={Stefan F Martin and Knut Adermann and Wolf Georg Forssmann and Michaela Kuhn},
  journal={Endocrinology},
  year={1999},
  volume={140 11},
  pages={
          5022-9
        }
}
Guanylin, an activator of the guanylyl cyclase C receptor in the apical membrane of intestinal epithelium, modulates intestinal fluid and electrolyte transport. The bioactive 15-amino acid peptide originally isolated from rat intestine represents the C-terminal part of a longer, 115-residue prepropeptide. The aim of the present study was to characterize the direction and molecular form in which guanylin is secreted from the colonic mucosa, as well as the mechanisms that trigger its secretion… CONTINUE READING

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