Regular transfusion lowers plasma free hemoglobin in children with sickle-cell disease at risk for stroke.

@article{Lezcano2006RegularTL,
  title={Regular transfusion lowers plasma free hemoglobin in children with sickle-cell disease at risk for stroke.},
  author={Nelson E Lezcano and Nadine Odo and Abdullah Kutlar and Donald Brambilla and Robert J. Adams},
  journal={Stroke},
  year={2006},
  volume={37 6},
  pages={1424-6}
}
BACKGROUND AND PURPOSE Intravascular hemolysis releases large amounts of free hemoglobin (PFH) in plasma of sickle-cell disease (SCD) patients. PFH has been associated with harmful endothelial actions including scavenging nitric oxide (NO). Whether PFH plays a role in stroke in SCD has not been examined. METHODS Serum levels of PFH, lactate dehydrogenase, and total bilirubin were measured in stored sera from children at risk for stroke treated in a randomized controlled trial of regular red… CONTINUE READING
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Laboratory parameters in patients randomized in the STOP study and their modification by transfusion

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