Regucalcin is under-expressed in human breast and prostate cancers: Effect of sex steroid hormones.

@article{Maia2009RegucalcinIU,
  title={Regucalcin is under-expressed in human breast and prostate cancers: Effect of sex steroid hormones.},
  author={Cl{\'a}udio Jorge Maia and Cec{\'i}lia R. A. Santos and Fernando de Lander Schmitt and S{\'i}lvia Socorro},
  journal={Journal of cellular biochemistry},
  year={2009},
  volume={107 4},
  pages={667-76}
}
Regucalcin plays an important role in maintenance of intracellular Ca(2+) homeostasis, suppresses cell proliferation, inhibits expression of oncogenes, and increases the expression of tumour suppressor genes. This suggests that regucalcin functions may be altered in cancer tissues. In this study the regucalcin expression in breast and prostate cancer cases was analysed by RT-PCR and immunohistochemistry showing that the mRNA and/or protein are under-expressed in these tumors. The effect of sex… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

Involvement of regucalcin as a suppressor protein in human carcinogenesis: insight into the gene therapy

Journal of Cancer Research and Clinical Oncology • 2014
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Calcium signalling and cancer cell growth.

Sub-cellular biochemistry • 2007
View 1 Excerpt
Highly Influenced

Function of alternative splicing.

Gene • 2005
View 2 Excerpts
Highly Influenced

Ca2+ homeostasis in apoptotic resistance of prostate cancer cells.

Biochemical and biophysical research communications • 2004
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…