Regucalcin is under-expressed in human breast and prostate cancers: Effect of sex steroid hormones.

  title={Regucalcin is under-expressed in human breast and prostate cancers: Effect of sex steroid hormones.},
  author={Cl{\'a}udio Jorge Maia and Cec{\'i}lia R. A. Santos and Fernando de Lander Schmitt and S{\'i}lvia Socorro},
  journal={Journal of cellular biochemistry},
  volume={107 4},
Regucalcin plays an important role in maintenance of intracellular Ca(2+) homeostasis, suppresses cell proliferation, inhibits expression of oncogenes, and increases the expression of tumour suppressor genes. This suggests that regucalcin functions may be altered in cancer tissues. In this study the regucalcin expression in breast and prostate cancer cases was analysed by RT-PCR and immunohistochemistry showing that the mRNA and/or protein are under-expressed in these tumors. The effect of sex… CONTINUE READING


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