Regressive logistic and proportional hazards disease models for within-family analyses of measured genotypes, with application to a CYP17 polymorphism and breast cancer.

@article{Cui2003RegressiveLA,
  title={Regressive logistic and proportional hazards disease models for within-family analyses of measured genotypes, with application to a CYP17 polymorphism and breast cancer.},
  author={Jisheng Cui and Amanda B Spurdle and Melissa C. Southey and Gillian S. Dite and Deon J. Venter and Margaret R. E. McCredie and Graham G. Giles and Georgia Chenevix-Trench and John L. Hopper},
  journal={Genetic epidemiology},
  year={2003},
  volume={24 3},
  pages={161-72}
}
Various statistical methods have been proposed to evaluate associations between measured genetic variants and disease, including some using family designs. For breast cancer and rare variants, we applied a modified segregation analysis method that uses the population cancer incidence and population-based case families in which a mutation is known to be segregating. Here we extend the method to a common polymorphism, and use a regressive logistic approach to model familial aggregation by… CONTINUE READING

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