Regression to the mean: implications for clinical trials of psychotropic agents in dementia.

@article{Cummings2004RegressionTT,
  title={Regression to the mean: implications for clinical trials of psychotropic agents in dementia.},
  author={Jeffrey L. Cummings and Rochelle E. Tractenberg and Anthony Gamst and Linda Teri and Donna A Masterman and Leon J. Thal},
  journal={Current Alzheimer research},
  year={2004},
  volume={1 4},
  pages={323-8}
}
Effective drug development depends on understanding and optimizing results from controlled clinical trials. A recent double-blind, randomized, controlled trial of the treatment of agitation in patients with Alzheimer's disease (AD) found no difference among the four arms of the study: haloperidol, trazodone, behavioral therapy, placebo. The current analysis was undertaken to further investigate the issues bearing on this outcome and to identify better means of detecting psychotropic effects in… CONTINUE READING
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