Regression of small-cell lung carcinoma in patients with paraneoplastic neuronal antibodies

@article{Darnell1993RegressionOS,
  title={Regression of small-cell lung carcinoma in patients with paraneoplastic neuronal antibodies},
  author={Robert B. Darnell and L Deangelis},
  journal={The Lancet},
  year={1993},
  volume={341},
  pages={21-22}
}

Paraneoplastic sensorimotor neuropathy associated with regression of small cell lung carcinoma

An elderly female smoker presented with nausea and anorexia and subsequently developed a progressive sensorimotor neuropathy with high titres of anti-Hu antibodies, which supports the theory that anti- Hu antibodies confer anti-tumour activity causing tumour regression.

Occult Small Cell Lung Cancer Associated with Paraneoplastic Neurologic Syndrome: Case Report

A patient with occult small cell lung cancer that was initially compounded by clinical features of a paraneoplastic neurologic syndrome is reported, which showed no evidence of disease for the next 18 months, whereas only a slight improvement in the neurologic disorders was observed after chemo-radiotherapy.

Paraneoplastic Sensory Neuronopathy and Spontaneous Regression of Small Cell Lung Cancer

This case supports the hypothesis that anti-Hu neurologic syndromes are the consequence of a misdirected immune response to small cell tumours.

Partial spontaneous remission of small cell lung carcinoma with neurologic symptom

It is assumed that the spontaneous remission of lung cancer was related to the immunologic response directed against the tumor, which is believed to be an important factor in the pathogenesis of paraneoplastic neurologic syndromes.

A Case of Spontaneous Regression of Small-cell Lung Cancer with Paraneoplastic Cerebellar Degeneration

IVIG and chemoradiation for PNS improve the neurological symptoms and prognosis and achieve a complete response, ultimately obtaining a long-term survival.

Paraneoplastic cerebellar degeneration in ovarian carcinoma: case report with review of immune modulation

A 56-year-old woman with stage IIIC serous ovarian carcinoma diagnosed 3 years prior developed progressive limb ataxia, and serum anti-Yo antibodies were positive, confirming the diagnosis of PCD.

Paraneoplastic limbic encephalitis associated with lung cancer

The results suggest patients with GABAB encephalitis might respond better to immunotherapy than the classical PLE patients with anti-Hu antibodies, and Lung cancer patients with PLE might have better outcome due to earlier diagnosis and prompt anti-cancer treatment.

Paraneoplastic cerebellar degeneration (PCD) associated with squamous cell carcinoma of the lung.

There was complete disappearance of Purkinje cells with reactive astrocytosis and these findings are compatible with paraneoplastic cerebellar degeneration (PCD), which no case of PCD has been reported previously in patients with squamous cell carcinoma of the lung.

Anti-Hu Encephalitis Associated With Small Cell Lung Cancer, A Case Report

This is a case report of a 66-years-old woman, with SCLC that has been diagnosed due to paraneoplastic encephalitis staining positive for anti-Hu antibodies.
...

References

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Anti‐Hu-Associated Paraneoplastic Encephalomyelitis/Sensory Neuronopathy A Clinical Study of 71 Patients

Patients with rapidly developing sensory neuropathy or symptoms of encephalomyelitis should be studied for the presence of the anti-Hu antibody; if the antibody is found, the possibility of small-cell lung cancer should be investigated.

Detection of the anti‐Hu antibody in the serum of patients with small cell lung cancer—A quantitative western blot analysis

The anti‐Hu antibody appears, when present, to be a good marker for small cell lung cancer and, whenPresent at high titer, for small Cell lung cancer associated with a paraneoplastic syndrome.

Spontaneous 19‐year regression of oat cell carcinoma with scalene node metastasis

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Antiserum from a patient with cerebellar degeneration identifies a novel protein in Purkinje cells, cortical neurons, and neuroectodermal tumors

Using a novel antineuronal autoantibody, anti-Nb antibody is identified and characterized antigens present in a subset of neurons in the CNS and in some neuroectodermal tumor lines, which appear to be unique in size and distribution of expression.

Cure of lung cancer from incomplete surgical resection.

Three patients with lung cancer have been cured by incomplete removal of the cancer, which has for 20 years been the policy of this unit when complete removal is not possible. In each patient

Multicenter long‐term safety and efficacy study of vigabatrin for refractory complex partial seizures

Based on this and other long-term data, clinical trials of vigabatrin have resumed in the United States and Canada and no toxicity other than reversible, dose-dependent side effects are reported.

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Part I: Molecular Biology of Cancer Molecular Methods in Oncology Section 1. Amplification Techniques Section 2. RNA Interference Section 3. cDNA arrays Section 4. Tissue arrays Section 5.