Regression of left ventricular hypertrophy in human hypertension with irbesartan.

  title={Regression of left ventricular hypertrophy in human hypertension with irbesartan.},
  author={Karin Malmqvist and Thomas Kahan and Magnus Edner and Claes Held and Anders H{\"a}gg and Lars Lind and Richard M{\"u}ller-Brunotte and Fredrik Nystr{\"o}m and Karl Peter Ohman and Mary D. Osbakken and J Ostergern},
  journal={Journal of hypertension},
  volume={19 6},
BACKGROUND The Swedish irbesartan left ventricular hypertrophy investigation versus atenolol (SILVHIA). OBJECTIVE Angiotensin II induces myocardial hypertrophy. We hypothesized that blockade of angiotensin II subtype 1 (AT1) receptors by the AT1-receptor antagonist irbesartan would reduce left ventricular mass (as measured by echocardiography) more than conventional treatment with a beta blocker. DESIGN AND METHODS This double-blind study randomized 115 hypertensive men and women with left… CONTINUE READING


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