Regression of glomerulosclerosis with high-dose angiotensin inhibition is linked to decreased plasminogen activator inhibitor-1.

@article{Ma2005RegressionOG,
  title={Regression of glomerulosclerosis with high-dose angiotensin inhibition is linked to decreased plasminogen activator inhibitor-1.},
  author={Li-jun Ma and Shinya Nakamura and Jean-Claude Aldigier and Michele Rossini and Haichun C. Yang and Xiubin Liang and Ichiro Nakamura and Carmelita Marcantoni and Agnes B. Fogo},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2005},
  volume={16 4},
  pages={
          966-76
        }
}
The potential and possible mechanisms for regression of existing glomerulosclerosis by angiotensin II type 1 receptor antagonist (AT1RA) and/or angiotensin I converting enzyme inhibitor (ACEI) were investigated. Adult male Sprague Dawley rats underwent 5/6 nephrectomy (Nx). Glomerulosclerosis was assessed by renal biopsy 8 wk later, and rats were divided into groups with equal biopsy sclerosis and treated for the next 4 wk until they were killed at 12 wk as follows: Control with no further… CONTINUE READING
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