Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides

@article{Mandelboim1995RegressionOE,
  title={Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides},
  author={Ofer Mandelboim and Ezra Vadai and Mati Fridkin and Anne Katz-Hillel and Michael S. Feldman and Gideon Berke and Lea Eisenbach},
  journal={Nature Medicine},
  year={1995},
  volume={1},
  pages={1179-1183}
}
The cure of micrometastases following surgery is the major goal of cancer immunotherapy. We have recently isolated tumour-associated antigen (TAA) peptides, MUT 1 and MUT 2, derived from a mutated connexin 37 gap-junction protein, from the malignant 3LL-D122 murine lung carcinoma. We now report that synthetic MUT 1 or MUT 2 induces effective antitumour cytoxic T lymphocytes. Peptide vaccines protect mice from spontaneous metastases of 3LL-D122 tumours. Moreover, peptide vaccines reduce… CONTINUE READING
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