Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides

@article{Mandelboim1995RegressionOE,
  title={Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides},
  author={O. Mandelboim and E. Vadai and M. Fridkin and Anne Katz-Hillel and M. Feldman and G. Berke and L. Eisenbach},
  journal={Nature Medicine},
  year={1995},
  volume={1},
  pages={1179-1183}
}
  • O. Mandelboim, E. Vadai, +4 authors L. Eisenbach
  • Published 1995
  • Medicine
  • Nature Medicine
  • The cure of micrometastases following surgery is the major goal of cancer immunotherapy. We have recently isolated tumour-associated antigen (TAA) peptides, MUT 1 and MUT 2, derived from a mutated connexin 37 gap-junction protein, from the malignant 3LL-D122 murine lung carcinoma. We now report that synthetic MUT 1 or MUT 2 induces effective antitumour cytoxic T lymphocytes. Peptide vaccines protect mice from spontaneous metastases of 3LL-D122 tumours. Moreover, peptide vaccines reduce… CONTINUE READING

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