Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus.

  title={Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus.},
  author={Katherine Esposito and Dario Giugliano and Francesco Nappo and Raffaele Marfella},
  volume={110 2},
BACKGROUND Postprandial hyperglycemia may be a risk factor for cardiovascular disease. We compared the effects of two insulin secretagogues, repaglinide and glyburide, known to have different efficacy on postprandial hyperglycemia, on carotid intima-media thickness (CIMT) and markers of systemic vascular inflammation in type 2 diabetic patients. METHODS AND RESULTS We performed a randomized, single-blind trial on 175 drug-naive patients with type 2 diabetes mellitus (93 men and 82 women), 35… CONTINUE READING


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