Regression of cardiac hypertrophy after closing an aortocaval fistula in rats.

@article{Gerdes1995RegressionOC,
  title={Regression of cardiac hypertrophy after closing an aortocaval fistula in rats.},
  author={Anthony Martin Gerdes and Linda C Clark and Joseph M. Capasso},
  journal={The American journal of physiology},
  year={1995},
  volume={268 6 Pt 2},
  pages={H2345-51}
}
To determine whether the series addition of sarcomeres observed during eccentric hypertrophic growth is reversible upon removal of the initiating stimulus, an aortocaval fistula was created and myocyte geometry evaluated at 2 and 12 wk after shunt occlusion. A 76% cardiac enlargement was produced in rats with an aortocaval fistula. This enlargement was reduced to 22 and 18% at 2 and 12 wk of fistula reversal, respectively. Hemodynamic performance was altered as a result of fistula induction as… CONTINUE READING
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