Regression models for disease prevalence with diagnostic tests on pools of serum samples.

@article{Vansteelandt2000RegressionMF,
  title={Regression models for disease prevalence with diagnostic tests on pools of serum samples.},
  author={Stijn Vansteelandt and Els Goetghebeur and Thomas Verstraeten},
  journal={Biometrics},
  year={2000},
  volume={56 4},
  pages={1126-33}
}
Whether the aim is to diagnose individuals or estimate prevalence, many epidemiological studies have demonstrated the successful use of tests on pooled sera. These tests detect whether at least one sample in the pool is positive. Although originally designed to reduce diagnostic costs, testing pools also lowers false positive and negative rates in low prevalence settings and yields more precise prevalence estimates. Current methods are aimed at estimating the average population risk from… CONTINUE READING
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