Regorafenib for cancer.

  title={Regorafenib for cancer.},
  author={Dirk Strumberg and Beate S Schultheis},
  journal={Expert opinion on investigational drugs},
  volume={21 6},
INTRODUCTION Regorafenib (BAY 73-4506) is a novel, orally active, diphenylurea multikinase inhibitor of VEGFR1-3, c-KIT, TIE-2, PDGFR-β, FGFR-1, RET, RAF-1, BRAF and p38 MAP kinase. AREAS COVERED This review covers the preclinical development of regorafenib as well as the pivotal Phase I studies. The safety profile of regorafenib is discussed in context with other oral multikinase inhibitors bearing a similar target profile. Current clinical developments, especially in colorectal cancer (CRC… CONTINUE READING
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