Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

@article{Mino2015Regnase1AR,
  title={Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms},
  author={Takashi Mino and Yasuhiro Murakawa and Akira Fukao and Alexis Vandenbon and Hans-Hermann Wessels and Daisuke Ori and Takuya Uehata and Sarang Tartey and Shizuo Akira and Yutaka Suzuki and Carola G. Vinuesa and Uwe Ohler and Daron M. Standley and Markus Landthaler and Toshinobu Fujiwara and Osamu Takeuchi},
  journal={Cell},
  year={2015},
  volume={161},
  pages={1058-1073}
}
Regnase-1 and Roquin are RNA binding proteins essential for degradation of inflammation-related mRNAs and maintenance of immune homeostasis. However, their mechanistic relationship has yet to be clarified. Here, we show that, although Regnase-1 and Roquin regulate an overlapping set of mRNAs via a common stem-loop structure, they function in distinct subcellular locations: ribosome/endoplasmic reticulum and processing-body/stress granules, respectively. Moreover, Regnase-1 specifically cleaves… CONTINUE READING
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