Registering clinical trials.

@article{Dickersin2003RegisteringCT,
  title={Registering clinical trials.},
  author={Kay Dickersin and Drummond Rennie},
  journal={JAMA},
  year={2003},
  volume={290 4},
  pages={
          516-23
        }
}
That it is not possible to find information about all initiated clinical trials is of international concern. This is a particular worry because scientists tend to publish their positive findings more often than their negative findings (publication bias). A comprehensive register of initiated clinical trials, with each trial assigned a unique identifier, would inform reviewers, physicians, and others (eg, consumers) about which trials had been started and directly address the problem of… Expand
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TLDR
The factors that define negative data and the various ways in which the publication of data can be influenced by those responsible at each stage of the publication process are discussed. Expand
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TLDR
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References

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Better Access to Information about Clinical Trials
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  • Medicine
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TLDR
The case for registering all clinical trials is now unanswerable, and it is suggested that there are many barriers to practicing evidence-based medicine, including the volume and complexity of the research that is being conducted and poor access to information about it. Expand
A clinical trials register for Europe
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For more than a decade, clinical trialists and their sponsors have been saying that they want all controlled clinical trials tagged and listed somewhere while they are in progress—preferably on anExpand
Publication bias and clinical trials.
TLDR
It appears that nonpublication was primarily a result of failure to write up and submit the trial results rather than rejection of submitted manuscripts, implying the existence of a publication bias of importance both to meta-analysis and the interpretation of statistically significant positive trials. Expand
Report from the panel on the Case for Registers of Clinical Trials at the Eighth Annual Meeting of the Society for Clinical Trials.
TLDR
The experience gleaned by those involved with two existing trial registers, the International Committee on Thrombosis and Haemostasis Registry and the Oxford Database of Perinatal Trials, can be used to provide insight into the issues generic to trial registration. Expand
Underreporting research is scientific misconduct.
TLDR
An extended use of prospective registration of trials at inception, as well as benefiting clinical research in other ways, could help people to play their respective roles in reducing underreporting of clinical trials. Expand
Publication bias: the case for an international registry of clinical trials.
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TLDR
A model is proposed for reviewing clinical trial results which is free from publication bias based on the selection of trials registered in advance in a registry, and the value and importance of an international registry of all clinical trials are illustrated. Expand
Keeping posted Why register clinical trials?-Revisited
TLDR
The main purpose of this column is first to serve as a clearinghouse for information about registers of clinical trials that are planned or in existence today, as it appears that the prospect of one large register of trials is unlikely to exist in the near future. Expand
Role of a research ethics committee in follow-up and publication of results
TLDR
The recruitment rate was lower than expected, and the results of only 21% of finished clinical trials were published in peer-reviewed journals 3 years after, so RECs should devote more effort and resources to assess public dissemination of results of clinical trials. Expand
How important is publication bias? A synthesis of available data.
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This article will review the major evidence available regarding publication bias and will suggest measures for overcoming the problem. Expand
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Even when the overall publication rate is high, such as for trials funded by the NIH, publication bias remains a significant problem and more reliable systems for maintaining information about initiated studies are needed. Expand
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