Regiospecific one-pot synthesis of pyrimido[4,5-d]pyrimidine derivatives in the solid state under microwave irradiations.

Abstract

Electron rich 6-[(dimethylamino)methylene]amino uracil 1, undergoes [4+2] cycloaddition reactions with various in situ generated glyoxylate imine and imine oxides 6 to provide novel pyrimido[4,5-d]pyrimidine derivatives of biological significance, after elimination of dimethylamine from the (1:1) cycloadducts and oxidative aromatisation. This procedure… (More)

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Cite this paper

@article{Prajapati2006RegiospecificOS, title={Regiospecific one-pot synthesis of pyrimido[4,5-d]pyrimidine derivatives in the solid state under microwave irradiations.}, author={Dipak Prajapati and Mukut Gohain and Ashim Jyoti Thakur}, journal={Bioorganic & medicinal chemistry letters}, year={2006}, volume={16 13}, pages={3537-40} }