Regioselectivity in the Sonogashira coupling of 4,6-dichloro-2-pyrone.

Abstract

The Sonogashira cross-coupling of 4,6-dichloro-2-pyrone with terminal acetylenes proceeds in good yields and high regioselectivity for the 6-position; dibenzylidene acetone (dba) type ligands play a non-innocent role in reactions mediated by Pd(dba)2/PPh3; theoretical studies indicate that C-6 oxidative addition is favoured both kinetically and… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.