Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin by the fungus Mucor ramannianus.

@article{Parshikov1999RegioselectiveTO,
  title={Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin by the fungus Mucor ramannianus.},
  author={I. Parshikov and J. Freeman and J. Lay and R. Beger and A. Williams and J. Sutherland},
  journal={FEMS microbiology letters},
  year={1999},
  volume={177 1},
  pages={
          131-5
        }
}
A strain of the saprobic fungus Mucor ramannianus, isolated from a forest, was used to demonstrate the potential for ciprofloxacin biotransformation by zygomycetes in the environment. The fungus carried out the regioselective N-acetylation of ciprofloxacin to a single product, which was purified from culture extracts by high-performance liquid chromatography. The metabolite was identified by mass and nuclear magnetic resonance spectrometry as 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-acetyl… Expand
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