Regioselective synthesis of multisubstituted 1,2,3-triazoles: moving beyond the copper-catalyzed azide-alkyne cycloaddition.

@article{Wei2016RegioselectiveSO,
  title={Regioselective synthesis of multisubstituted 1,2,3-triazoles: moving beyond the copper-catalyzed azide-alkyne cycloaddition.},
  author={Fang Wei and Weiguo Wang and Yudao Ma and Chen-Ho Tung and Zhenghu Xu},
  journal={Chemical communications},
  year={2016},
  volume={52 99},
  pages={14188-14199}
}
Copper(i)-catalyzed azide-alkyne cycloaddition (CuAAC) is an essential "click chemistry" reaction that is widely used in chemical biology, medicinal chemistry and materials science. The CuAAC reaction of terminal alkynes provides a mild and efficient synthesis of 1,4-disubstituted 1,2,3-triazoles. However, the click reaction of internal alkynes with azides, giving trisubstituted triazoles, is very challenging. This feature article highlights the recent progress addressing this fundamental… CONTINUE READING
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