Regioselective syntheses of sulfated polysaccharides: specific anti-HIV-1 activity of novel chitin sulfates.

@article{Nishimura1998RegioselectiveSO,
  title={Regioselective syntheses of sulfated polysaccharides: specific anti-HIV-1 activity of novel chitin sulfates.},
  author={Shin-Ichiro Nishimura and Hirofumi Kai and Keita Shinada and Takashi Yoshida and Seiichi Tokura and Keisuke Kurita and Hidetoshi Nakashima and Naoki Yamamoto and Toshiyuki Uryu},
  journal={Carbohydrate research},
  year={1998},
  volume={306 3},
  pages={427-33}
}
A novel and convenient method for the regioselective syntheses of sulfated analogs of chitin and chitosan is described in relation to studies on structure-biological activity. Fully protected, soluble derivatives of chitosan were found to be useful intermediates for the syntheses of a novel class of sulfated polysaccharides, 2-acetamido-2-deoxy-3-O-sulfo-(1-->4)-beta-D-glucopyranan (3-sulfate, 3S, 4) and (1-->4)-2-deoxy-2-sulfoamido-3-O-sulfo-(1-->4)-beta-D-glucopyranan (2,3-disulfate, 23-S, 3… CONTINUE READING

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