Regioselective reaction: synthesis, characterization and pharmacological studies of some new Mannich bases derived from 1,2,4-triazoles.

@article{Isloor2009RegioselectiveRS,
  title={Regioselective reaction: synthesis, characterization and pharmacological studies of some new Mannich bases derived from 1,2,4-triazoles.},
  author={Arun M. Isloor and Balakrishna Kalluraya and Prashanth Shetty},
  journal={European journal of medicinal chemistry},
  year={2009},
  volume={44 9},
  pages={3784-7}
}
In the present investigation, a series of new 4[(3-substituted-1H-pyrazol-4-yl)methyleneamino]-5-substituted-2-[(4-methylpiperzine-1-yl)methyl]-2H-1,2,4-triazole-3(4H)-thiones (4) were synthesized by the aminomethylation of 4-(3-substituted-1H-pyrazol-3-yl)methyleneamino-5-substituted-4H-1,2,4-triazole-3-thiols (3) with formaldehyde and N-methylpiperzine. These newly synthesized Schiff and Mannich bases were characterized by IR, (1)H NMR, mass spectral data and elemental analyses. These… CONTINUE READING
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