Regioselective oxidation of phospho‐NSAIDs by human cytochrome P450 and flavin monooxygenase isoforms: implications for their pharmacokinetic properties and safety

@article{Xie2012RegioselectiveOO,
  title={Regioselective oxidation of phospho‐NSAIDs by human cytochrome P450 and flavin monooxygenase isoforms: implications for their pharmacokinetic properties and safety},
  author={Gang Xie and Chi Chun Wong and Ka-Wing Cheng and Liqun Huang and Panayiotis Constantinides and Basil Rigas},
  journal={British Journal of Pharmacology},
  year={2012},
  volume={167}
}
  • G. Xie, C. Wong, B. Rigas
  • Published 1 September 2012
  • Biology, Medicine
  • British Journal of Pharmacology
Phospho‐ibuprofen (MDC‐917) and phospho‐sulindac (OXT‐328) are highly effective in cancer and arthritis treatment in preclinical models. Here, we investigated their metabolism by major human cytochrome P450s (CYPs) and flavin monooxygenases (FMOs). 
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  • 2019
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Identification of roles for FMO1 and FMO5 in endogenous metabolism has implications for drug therapy and initiates an exciting area of research.
Recent Developments in Chimeric NSAIDs as Safer Anti‐Inflammatory Agents
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This review deals with approaches and strategies that have been employed in the last two decades and are being used currently in the design and development of safer NSAIDs.
Relative Expression of Mouse Udp-Glucuronosyl Transferase 2b1 Gene in The Livers, Kidneys, And Hearts: The Influence of Nonsteroidal Anti-Inflammatory Drug Treatment.
TLDR
It was found that the mouse ugt2b1 gene was mainly expressed in the liver, as 14-day administration of different NSAIDs caused alterations in the expression of this gene, which may influence the metabolism of xenobiotic and endogenous compounds.
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