Regioselective formation of the three disulfide bonds of a 35-residue insect peptide.

Abstract

PMP-D2, a 35-residue peptide containing three disulfide bonds, was synthesized on solid-phase using 9-fluorenylmethoxy-carbonyl (Fmoc) as alpha-NH2 protection and simultaneous air oxidation of the six cysteines for formation of its disulfide bonds. The overall yield was 13%. As very little research has been done on the regioselective formation of three… (More)

Topics

  • Presentations referencing similar topics