Regioselective acylation of flavonoids catalyzed by immobilized Candida antarctica lipase under reduced pressure
@article{Passicos2004RegioselectiveAO, title={Regioselective acylation of flavonoids catalyzed by immobilized Candida antarctica lipase under reduced pressure}, author={Emilie Passicos and Xavier Santarelli and Denis Coulon}, journal={Biotechnology Letters}, year={2004}, volume={26}, pages={1073-1076} }
A single-step acylation of rutin and naringin, catalyzed by immobilized Candida antarctica lipase B in 2-methyl-2-butanol, occurred preferentially on the primary hydroxyl group. Using palmitic methyl ester as acyl donor, the acylation rate of naringin was 10-fold higher than that of rutin. Under optimal conditions, i.e. a molar ratio acyl donor/naringin of 7:1 and 200 mbar, 92% naringin was acylated.
37 Citations
Controllable Regioselective Acylation of Flavonoids Catalyzed by Lipase in Microreactors
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A method for regioselective acylation of flavonoids (naringin and naringin dihydrochalcone) in a flow microreactor using Lipozyme TL IM from Thermomyces lanuginosus as the catalyst has been…
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In this study, flavonoid rutin was acylated with lauric acid in acetone catalyzed by an immobilized lipase from Candida antarctica. In addition to the reaction not being well studied, the…
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Biocatalytic synthesis and antitumor activities of novel silybin acylated derivatives with dicarboxylic acids.
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Lipase B from Candida antarctica — the wide applicable biocatalyst in obtaining pharmaceutical compounds
- Biology, ChemistryMedical Research Journal
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It can be concluded, that CAL-B is an enzyme with a wide application in the biosynthesis of compounds with therapeutic activity, which could be also applied in the kinetic resolution of compounds being building blocks, derivates of drugs or conjugated forms.
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This work describes the reaction of naringin withCastor oil containing ricinoleic acid, castor oil's major fatty acid component, using immobilized lipase from Candida antarctica, and determined the chemical structure of naredin 6″-ricinoleate, which was determined using NMR analysis.
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