Regioselective acylation of flavonoids catalyzed by immobilized Candida antarctica lipase under reduced pressure

  title={Regioselective acylation of flavonoids catalyzed by immobilized Candida antarctica lipase under reduced pressure},
  author={Emilie Passicos and X. Santarelli and D. Coulon},
  journal={Biotechnology Letters},
A single-step acylation of rutin and naringin, catalyzed by immobilized Candida antarctica lipase B in 2-methyl-2-butanol, occurred preferentially on the primary hydroxyl group. Using palmitic methyl ester as acyl donor, the acylation rate of naringin was 10-fold higher than that of rutin. Under optimal conditions, i.e. a molar ratio acyl donor/naringin of 7:1 and 200 mbar, 92% naringin was acylated. 
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