Regioselective O-substitution of p-tert-butylcalix[7]arene.

  title={Regioselective O-substitution of p-tert-butylcalix[7]arene.},
  author={Marco Martino and Luisa Gregoli and Carmine Gaeta and Placido Neri},
  journal={Organic letters},
  volume={4 9},
[structure: see text]. The first examples of selectively functionalized calix[7]arenes have been obtained by weak-base promoted O-alkylation or O-benzoylation of p-tert-butylcalix[7]arene. Mono-, 1,3- and 1,4-disubstituted calix[7]arenes have been obtained in workable yields, while the 1,2,4,6-tetrasubstitution was achieved with surprisingly high… CONTINUE READING