Regioselective A-ring iodination of estradiol diacetates.

@article{Ali1987RegioselectiveAI,
  title={Regioselective A-ring iodination of estradiol diacetates.},
  author={H. Ali and M. Ghaffari and J. V. van Lier},
  journal={Journal of steroid biochemistry},
  year={1987},
  volume={28 1},
  pages={
          21-3
        }
}
Treatment of estrone or estradiol acetate with thallium trifluoroacetate in TFA and subsequent reaction with KI gave the 2-iodoestrogens as the major product. In the case of estradiol diacetate, treatment of the thallation product with [125I]NaI, using the same reaction conditions, gave exclusively the 2-iodo isomer. Thus, regioselectivity combined with rapidity, renders this procedure particularly suitable for A-ring radioiodination of estradiol with short-lived isotopes. 

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