Regioselective 1,4- and 1,6-Conjugate Additions of Grignard Reagent-Derived Organozinc(II)ates to Polyconjugated Esters.

Abstract

Regioselective synthetic methods were developed for 1,4- and 1,6-conjugate additions of Grignard reagent-derived organozinc(II)ates to malonate-derived polyconjugated esters. By taking advantage of the tight ion-pair control of organozinc(II)ates, it was possible to switch between 1,4- and 1,6-conjugate additions by introducing a terminal ethoxy moiety in… (More)
DOI: 10.1021/acs.orglett.6b01774

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Cite this paper

@article{Hatano2016Regioselective1A, title={Regioselective 1,4- and 1,6-Conjugate Additions of Grignard Reagent-Derived Organozinc(II)ates to Polyconjugated Esters.}, author={Manabu Hatano and Mai Mizuno and Kazuaki Ishihara}, journal={Organic letters}, year={2016}, volume={18 18}, pages={4462-5} }