Regions outside of conserved PxxPxR motifs drive the high affinity interaction of GRB2 with SH3 domain ligands.

Abstract

SH3 domains are evolutionarily conserved protein interaction domains that control nearly all cellular processes in eukaryotes. The current model is that most SH3 domains bind discreet PxxPxR motifs with weak affinity and relatively low selectivity. However, the interactions of full-length SH3 domain-containing proteins with ligands are highly specific and… (More)
DOI: 10.1016/j.bbamcr.2015.06.002

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Cite this paper

@article{Bartelt2015RegionsOO, title={Regions outside of conserved PxxPxR motifs drive the high affinity interaction of GRB2 with SH3 domain ligands.}, author={Rebekah Ruth Bartelt and Jonathan Light and Aldo Vacaflores and Alayna Butcher and M. Karuppasamy Pandian and Piers Nash and Jon C. D. Houtman}, journal={Biochimica et biophysica acta}, year={2015}, volume={1853 10 Pt A}, pages={2560-9} }