Regions of low endothelial shear stress are the sites where coronary plaque progresses and vascular remodelling occurs in humans: an in vivo serial study.

@article{Stone2007RegionsOL,
  title={Regions of low endothelial shear stress are the sites where coronary plaque progresses and vascular remodelling occurs in humans: an in vivo serial study.},
  author={Peter H. Stone and Ahmet U. Coskun and Scott Kinlay and Jeffrey J. Popma and Milan Sonka and Andreas Wahle and Yerem Yeghiazarians and Charles Maynard and Richard E. Kuntz and Charles L. Feldman},
  journal={European heart journal},
  year={2007},
  volume={28 6},
  pages={705-10}
}
AIM We performed serial intracoronary studies of patients with stable coronary artery disease (CAD) to investigate the relationships among baseline endothelial shear stress (ESS), CAD progression, and vascular remodelling. Local haemodynamic factors are critical determinants of plaque progression, vascular remodelling, and clinical CAD manifestations. METHODS AND RESULTS The 3-D anatomy of coronary arteries with lumen obstruction <50% was determined by fusing intracoronary ultrasound and… CONTINUE READING