Regions of genomic instability on 22q11 and 11q23 as the etiology for the recurrent constitutional t(11;22).

@article{Kurahashi2000RegionsOG,
  title={Regions of genomic instability on 22q11 and 11q23 as the etiology for the recurrent constitutional t(11;22).},
  author={Hiroki Kurahashi and Tamim H. Shaikh and Peng Hu and B. A. Roe and Beverly S. Emanuel and Marcia L. Budarf},
  journal={Human molecular genetics},
  year={2000},
  volume={9 11},
  pages={
          1665-70
        }
}
The constitutional t(11;22)(q23;q11) is the only known recurrent, non-Robertsonian translocation. To analyze the genomic structure of the breakpoint, we have cloned the junction fragments from the der(11) and der(22) of a t(11;22) balanced carrier. On chromosome 11 the translocation occurs within a short, palindromic AT-rich region (ATRR). Likewise, the breakpoint on chromosome 22 has been localized within an ATRR that is part of a larger palindrome. Interestingly, the 22q11 breakpoint falls… CONTINUE READING

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