Regionally specific neuronal expression of human APOE gene in transgenic mice.

@article{Xu1998RegionallySN,
  title={Regionally specific neuronal expression of human APOE gene in transgenic mice.},
  author={P T Xu and John R. Gilbert and H L Qiu and T R Rothrock-Christian and Daniel L. Settles and A. D. Roses and Donald E. Schmechel},
  journal={Neuroscience letters},
  year={1998},
  volume={246 2},
  pages={65-8}
}
Apolipoprotein E (APOE, gene; apoE, protein) is a susceptibility gene for late-onset Alzheimer's disease (AD). To examine whether neurons can synthesize apoE, we performed in situ hybridization on brain tissue of transgenic mice carrying genomic constructs for the three major human APOE alleles. We find human APOE mRNA in glial cells of cerebellum, striatum and cerebral cortex and also in neurons of cerebral cortex, corresponding to apoE localization in humans. Synthesis of apoE by neurons… CONTINUE READING

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Mentioned Connections BETA
Alzheimer's DiseaseAssociated with malfunction of gene productApolipoprotein E
Apolipoprotein E ( APOE , gene ; apoE , protein ) is a susceptibility gene for late - onset Alzheimer 's disease ( AD ) .
Apolipoprotein E ( APOE , gene ; apoE , protein ) is a susceptibility gene for late - onset Alzheimer 's disease ( AD ) .
Apolipoprotein E ( APOE , gene ; apoE , protein ) is a susceptibility gene for late - onset Alzheimer 's disease ( AD ) .
Apolipoprotein E ( APOE , gene ; apoE , protein ) is a susceptibility gene for late - onset Alzheimer 's disease ( AD ) .
Apolipoprotein E ( APOE , gene ; apoE , protein ) is a susceptibility gene for late - onset Alzheimer 's disease ( AD ) .
Apolipoprotein E ( APOE , gene ; apoE , protein ) is a susceptibility gene for late - onset Alzheimer 's disease ( AD ) .
Apolipoprotein E ( APOE , gene ; apoE , protein ) is a susceptibility gene for late - onset Alzheimer 's disease ( AD ) .
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