Regionally specific changes in extracellular noradrenaline following chronic idazoxan as revealed by in vivo microdialysis.

@article{Thomas1994RegionallySC,
  title={Regionally specific changes in extracellular noradrenaline following chronic idazoxan as revealed by in vivo microdialysis.},
  author={D N Thomas and David J. Nutt and R. Bruce Holman},
  journal={European journal of pharmacology},
  year={1994},
  volume={261 1-2},
  pages={53-7}
}
The selective alpha 2-adrenoceptor antagonist idazoxan was administered chronically (0.8 mg/kg per h) to rats for a period of 10 days via osmotic minipumps. On day 11, 24 h after removal of the pumps, the rats were anaesthetised and microdialysis probes were implanted into either the frontal cortex or hippocampus. Basal noradrenaline release in the frontal… CONTINUE READING