Regionally selective effects of intracerebral dopamine infusion on sensorimotor gating of the startle reflex in rats

@article{Swerdlow1992RegionallySE,
  title={Regionally selective effects of intracerebral dopamine infusion on sensorimotor gating of the startle reflex in rats},
  author={Neal R. Swerdlow and Simon Caine and Mark A. Geyer},
  journal={Psychopharmacology},
  year={1992},
  volume={108},
  pages={189-195}
}
Systemic administration of dopamine (DA) agonists markedly disrupts sensorimotor gating in rats as measured by prepulse inhibition (PPI) of the acoustic startle response. A qualitatively similar, but quantitatively weaker disruption of PPI follows DA infusion into the nucleus accumbens (NAC). The present study was designed to determine whether forebrain DA terminal fields other than the NAC contribute to the DAergic modulation of PPI. PPI was impaired significantly after infusion of DA (0–40 µg… CONTINUE READING

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Sensorimotor gating of the startle reflex is mediated by ventral pallidal efferents to the pedunculopontine nucleus

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