Regionally localized thinning of the cerebral cortex in schizophrenia.

  title={Regionally localized thinning of the cerebral cortex in schizophrenia.},
  author={Gina R. Kuperberg and Matthew R Broome and Philip K. McGuire and Anthony S. David and Marianna Eddy and Fujiro Ozawa and Donald C. Goff and W. Caroline West and Steven C. R. Williams and A van der Kouwe and David H. Salat and Anders M. Dale and Bruce Fischl},
  journal={Archives of general psychiatry},
  volume={60 9},
BACKGROUND Schizophrenia is characterized by small reductions in cortical gray matter volume, particularly in the temporal and prefrontal cortices. The question of whether cortical thickness is reduced in schizophrenia has not been addressed using magnetic resonance imaging (MRI) techniques. Our objectives were to test the hypothesis that cortical thinning in patients with schizophrenia (relative to control subjects) is greater in temporal and prefrontal regions of interest (ROIs) than in… CONTINUE READING
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